Improver

Hasnain Malik

Project Team Leader & Medicinal Chemist at the Novartis Institutes for BioMedical Research

Cambridge, Massachusetts

An innovative and results-driven project team leader with extensive knowledge in medicinal chemistry, SAR evaluation, and progression of chemotypes from HTS to IND. Experience working within cross-functional teams on portfolio prioritization, BD due diligence activities, disease pathways, target selection, design of biological assays, project strategy, and high-throughput screening approaches. Proven skill in synthetic route development for scale-ups (internal & CRO). Strong advocate of a team-based approach to cross-functional problem solving. Extensive experience collaborating across NIBR sites and with contract research organizations. Directing an industrial‒academic precompetitive partnership; key-contributor to a NIBR-biotech collaboration on next-generation targeted protein degradation therapies. Subjects of expertise include (1) Disease Areas: immuno-oncology, respiratory disease, cardiovascular disease, neuroscience, autoimmune disease; (2) Target Classes: kinase and pseudokinase proteins, membrane transport proteins, transcription factors; (3) Medchem Modalities/Approaches: noncovalent inhibitors, covalent inhibitors, targeted protein degradation (molecular glues and bifunctionals/PROTACs), the use of DNA-encoded library technologies, structure-based drug design, phenotypic, and target-based drug discovery.

---

Experience:

• Senior Principal Scientist (Novartis Institutes for BioMedical Research (NIBR))
• Principal Scientist I (Novartis Institutes for BioMedical Research)
• Graduate Student Research Assistant (University of Michigan)
• Postdoctoral Research Fellow (University of Toronto)
• Lecturer (University of Toronto)
• Principal Scientist II (Novartis Institutes for BioMedical Research (NIBR))
• Graduate Student Research Assistant (University of Michigan)
• Medicinal Chemistry Intern (Sanofi)
• Process Chemistry Intern (Merck)
• Presidential Postdoctoral Fellow (Novartis Institutes for BioMedical Research)

Skills: